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PMID: 41883513 Alexander L et al

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Over time, patients may experience a turning in of the knees, known as valgus deformity, and advanced arthritis that eventually requires joint replacement surgery

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This lack of restorative sleep further degrades mitochondrial function and immune stability, ensuring that the patient wakes up the next morning even more depleted and more susceptible to mast cell triggers, perpetuating a vicious cycle of exhaustion and hyperarousal

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