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4% (placebo) due to adverse events Clinical Significance: This pivotal Phase 2 study established cagrilintide as an effective monotherapy for obesity, producing weight loss competitive with GLP-1 agonists but through a distinct mechanism
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While standard capsules may cause mild bloating or cramping due to poor absorption and synthetic fillers, these issues are often avoidable
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GLP-1R agonists exhibit protective and regulatory effects on blood glucose levels but have been linked to the inhibition of tumor cell proliferation in most cancer cases, as seen in vitro and summarized in Table 1 [51, 73]
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