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By modifying the OXM peptide sequence with an amino acid-peptide substitution at position 2 to prevent DPP-4 action, in addition to a cholesterol-peptide conjugate, Pocai and colleagues were the first group to show that synthetic dual-agonists were an effective treatment strategy in an animal model
We found that the effect of liraglutide to increase cell PC1/3 mRNA expression occurred in a subcluster of cells and was associated with increased expression of other celllike genes, which we confirmed by IHC
FIGURE 4 FIGURE 5 The irradiation at 630 nm did not induce any photoinactivation effect, even using the maximum light dose (maximum exposure time of 1 h
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