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Systemic toxicity-collectively termed local anesthetic systemic toxicity (LAST)-necessitates prompt airway control, seizure suppression with benzodiazepines, and lipid emulsion therapy, which sequesters lipophilic drug molecules and improves hemodynamic stability

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Side Effects & Safety Per REDEFINE 1 and the Lau (2021) phase 2 program, trial-reported adverse events include: Nausea -- most common (25-40%)

This different mechanism may explain why combining cagrilintide with GLP-1 therapy (CagriSema) produces greater weight loss than either alone

Combination therapy evolution The future of hair restoration increasingly points toward multi-mechanism combination therapies rather than single-agent approaches

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