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If a patient has been stable on a submaximal dose (below 15 mg weekly) for at least four weeks and has tolerated the current dose well, increasing to the next dose level may restore weight loss momentum
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This flexibility makes daily use more convenient whilst maintaining medication stability for the in-use period
doi: 10.1542/peds.109.4.622 79
doi: 10.1016/j.cmet.2017.10.009 112 CannonBNedergaardJ
10.1186/s40168-021-01126-6 Summary Keywords butyrate, diabetes, GLP-1, gut microbiota, leonurine, MPC2 Citation Zhang Y, Chen W, Yu X, Feng J, Sammad A, Wang Z and Yin K (2026) Leonurine ameliorates experimental type 2 diabetes through gut microbiota remodeling, enhanced butyrate production, and MPC2 activation to restore GLP-1 secretion
