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5-amino-1mq successfully inhibits NNMT in cell cultures and animal models

in this form it is essential for conversion of methylmalonate to succinate and synthesis of methionine from homocysteine (a reaction which also requires folate)

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Studies show by inhibiting NNMT, the 5 amino compound prevents unnecessary methylation of nicotinamide, thus preserving NAD+ for energy metabolism

Cyanocobalamin contains a cyanide group attached to the cobalamin molecule

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