APAP overdose leads to excessive generation of the highly reactive metabolite n-acetyl-p-benzoquinone imine (NAPQI), which depletes glutathione (GSH), increases oxidative stress, and causes mitochondrial dysfunction, finally triggering immune response-mediated hepatotoxicity and massive hepatocytes necrosis [15, 16]
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Obviously, the oligomerization is not the only mechanism underlying AGE-RAGE axis operation
10.3390/toxics10110665 38 HuF.GuoQ.WeiM.HuangZ.ShiL.ShengY.et al (2020)
2.1 Antioxidant properties Many individuals suffering from chronic diseases such as Parkinsons disease, cardiovascular disease, chronic fatigue syndrome, arthritis, and cancer have low glutathione levels
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