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Deficiency of glutathione puts the cell at risk for oxidative damage

Bose P, MD, Masarova L, MD, Pemmaraju N, MD, Bledsoe SD, Daver N, MD, Jabbour EJ, MD, Kadia TM, MD, Estrov ZE, MD, Kornblau SM, MD, Andreeff M , MD, PhD, Cortes JE, MD, Jain N, MD, Borthakur G, MD, Alvarado Y, MD, Huynh-Lu J, Assistant P, Nguyen-Cao MM, Assistant P, Richie MA, Dobbins MH, McCrackin SA, Zhou L, Pierce SA, BSN, BA, Wang X, MS, Pike AM, RN, Garcia-Manero G, MD, Kantarjian H, MD, Verstovsek S, MD, PhD

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[1] Updated international guidelines were published in 2022, which resulted in some simplification in diagnosis and the removal of antacids as a possible adjunct therapy

Nearly all G6PD pathogenic variants are single nucleotide missense variants resulting in the substitution of a single amino acid

In fact, AOD stands for Advanced Obesity Drug, and it was designed specifically to combat fat