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A double-blind, placebo-controlled pilot study involving 26 healthy elderly subjects revealed that participants who received 1 mg of melatonin nightly for four weeks showed improved performance on the California Verbal Learning Test-interference subtest compared to those who received a placebo [221]
t = 0.79, p = 0.44)
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The EGR-1/NAB2 feedback regulatory loop appears to create self-sustaining repair programs, explaining why effects continue well after administration stops
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