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Evidence: Systematic review shows B12 significantly improves diabetic neuropathy symptoms vs placebo (Hasan et al., 2019)

Angiotensin-converting enzyme inhibitors, angiotensin-receptor blockers, and risk of appendicitis

Ugele et al., 2003)

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It must be kept refrigerated at 2-8C at all times and used within the timeframe dictated by laboratory protocols (typically 3-4 weeks before degradation begins)

34 Referral to a specialist in these procedures can be considered if medical therapy alone does not produce the desired results and the patient is not a candidate for or has declined metabolic-bariatric surgery