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This caloric deficit, rather than an increase in metabolic rate, is the main driver of weight loss observed in clinical trials

MASH resolved in patients treated with tirzepatide at one of three doses Launched in 2019, the SYNERGY-NASH trial evaluated tirzepatide in 196 overweight adults, ages 18-80, with biopsy-proven MASH and stage 2 or 3 liver fibrosis, reflecting moderate to significant fibrosis that hasnt progressed to cirrhosis

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