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10.20517/cdr.2019.10 177 WangY.YangL.MaoL.ZhangL.ZhuY.XuY.et al (2022)

Both were successful (we mean people showed improvement :)) but our Azelaic acid derivative was combined with other actives so it's hard to know what to attribute to this guy only

The risk of introducing bacteria can lead to infection, abscesses, and a systemic inflammatory response in test subjects, completely confounding any data you are trying to collect