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Patients often describe feeling as though they are thinking through a haze, struggling to find words, or experiencing delayed mental processing

However, the incidence of gastrointestinal events, discontinuations due to adverse events, and mean increase in pulse rate were higher with orforglipron than oral semaglutide

Figure 31: Photograph of Professor Bernard Thorens, credit Center for Integrative Genomics, University of Lausanne

Success is defined by tolerance and sustainability rather than intensity of side effects

Bioavailability through oral routes is generally lower than subcutaneous injection, which means effective dosing may differ

Depending on the size and number of areas treated