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Individualised incretin-based treatment for type 2 diabetes

In cells with NRF2 activation, most glutamate is secreted, and cystine is imported by the SLC7A11 (xCT) antiporter mechanism 47 (Fig

But when it comes to weight, it gets personal

Because you are eating less and your metabolism is shifting, the margin for overexertion is smaller than usual

Early data also suggest potential benefits in liver disease, obstructive sleep apnea, chronic respiratory disorders, neurodegenerative and psychiatric conditions, reproductive dysfunction, obesity-associated cancers, and sepsis, although these remain investigational

The clinic notes that monitoring metabolic rate can help adjust the plan as weight loss changes metabolism