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In addition to slowing stomach emptying, which helps you feel full longer, GLP1 also directly regulates your appetite, making it easier to control food cravings

This action is working in conjunction with the brain as it influences appetite suppression and energy expenditure by interacting with neuronal circuits that regulate hunger and fullness (Zhang et al

The regulation of GSH is well reported by Lu [11], and its role is illustrated in Figure 1

In humans, where C-cell GIP receptor expression appears to be lower, this effect may be minimal GIP and thyroid blood flow: Some preclinical data suggest GIP influences thyroid gland blood flow, which could theoretically affect hormone production and levothyroxine absorption in patients with remaining thyroid tissue No adverse thyroid effects in trials: In the SURMOUNT and SURPASS clinical trials, tirzepatide did not produce clinically significant changes in thyroid function tests in participants with normal thyroid function The presence of GIP receptors on thyroid tissue is an area of active research

Whether or not it gets treated, that's a whole other can of worms when do we treat it, who's going to benefit

Mounjaro is FDA-approved for type 2 diabetes management