Macrophage Polarization Your immune system contains macrophages that can either promote inflammation (M1 type) or support tissue repair (M2 type)
10.1016/j.phrs.2017.12.020 9 BahadoranZ.TohidiM.NazeriP.MehranM.AziziF.MirmiranP
Hyperglycemia and lipotoxicity drive sustained ROS production through NADPH oxidase (NOX4), mitochondrial respiratory chain complexes I and III, and xanthine oxidase, while concurrently depleting antioxidant defenses such as glutathione (GSH), superoxide dismutase (SOD2), and catalase
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