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Cardiovascular markers: Reductions in non-HDL cholesterol and systolic blood pressure were observed, suggesting broader metabolic benefits beyond weight loss
Factors, including water retention, hormonal fluctuations, and starting at the lower 2.5 mg dose, can delay visible results
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mild, transient hypoglycemia may occur, especially when fasting
This is usually temporary and tends to subside as your body adjusts
The post-discontinuation phase remains the least investigated, although extension studies consistently show that weight regain occurs rapidly, with patients regaining up to two-thirds of the lost weight within one year after withdrawal ( As the field evolves, questions remain about whether the future of obesity and diabetes management will prioritize pharmacotherapy, lifestyle, or a hybrid approach, especially given the challenges of long-term adherence and the broader health impacts of lifestyle change ( This narrative review synthesizes current evidence on GLP-1RAs, including both conventional single-agent therapies and dual GIP/GLP-1 receptor agonists, versus exercise, their combined effects, and the implications for future clinical and public health priorities
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