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Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs) are a highly efficacious class of drugs for the treatment of patients with type 2 diabetes (T2D) [9, 10]
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In vitro and in vivo studies have evaluated the biological functions of GHR in breast cancer by silencing GHR and showed that GHR reduction leads to the inhibition of cell proliferation, the cell-cycle arrest in G1-S phase transition, tumor growth, and cell apoptosis induction of breast cancer cell lines, speculating these effects might be due to the inhibition of the Raf/MEK/ERK signaling pathway (Zhu et al., 2020)
Increased activity of insulin-like growth factor (IGF) in osteoblastic cells in the presence of growth hormone (GH): positive correlation with the presence of the GH-induced IGF-binding protein BP-3
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