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In some rare cases, patients can develop a painful condition called acute pancreatitis

found that base modification could considerably reduce the hepatotoxicity of gapmer ASO, 245 providing insights for developing new gapmer ASOs

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Current studies suggest that peripherally administered GLP-1RA has low concentrations in the cerebrospinal fluid, and higher doses or improved delivery systems (e.g., nanoparticles, liposome encapsulation) may be needed to increase brain exposure