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Carnitine has a protective effect on glaucoma-induced retinal ganglion cells injury by reducing the expression of typical markers of cell stress, such as glial fibrillary acidic protein (GFAP), inducible nitric oxide synthase (iNOS), ubiquitin and caspase-3, and reducing the level of the lipid peroxidation product malondialdehyde (MDA) [318]

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This is an important consideration for future studies due to the larger effect size in risk of PDAC observed in patients with new onset compared with longstanding diabetes (typically defined as 3 years duration) 46

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Therefore, it is plausible that the reduction of this genus, as observed here, is likely to reflect the improved protein utilization by the host due to the increased NR

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