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The reported adverse reactions following parenteral administration of vitamin B12 include: Generalized : Anaphylaxis and death Cardiovascular : Pulmonary edema and congestive cardiac/heart failure during early treatment
However, these cardiovascular applications require particularly careful consideration given the potential risks associated with promoting angiogenesis in patients who may have undiagnosed malignancies or other conditions where angiogenesis promotion could be detrimental
Staiger D, Stock JH
Rare but serious risks include pancreatitis, gallbladder disease, hypoglycemia, allergic reaction, and a specific thyroid tumor signal
