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Age-associated microenvironmental changes highlight the role of PDGF-C in ER+ breast cancer metastatic relapse
Cardiovascular risk profiles: a cross-sectional study evaluating the REWIND, LEADER and SUSTAIN-6 trial populations
The research shows that GLP-1 receptor agonists reduce synovial inflammation and lower cytokine levels in rheumatoid arthritis models [10]
S2CID 23075151
Whilst attractive as a theory, it should, nevertheless, be borne in mind that the majority of the studies cited above have been carried out in rodents or have examined isolated islets/-cells under in vitro or ex vivo conditions, and whether a local pancreatic DPP-4/GLP-1 system plays an important role in normal human physiology or in the pharmacological effect of DPP-4 inhibitors is not clear
The administration of GLP-1RA or exendin-4 to rats fed a high-fat diet resulted in an increase in the OPG/RANKL ratio and a reduction in the degree of bone loss
