Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) study
Resulting barcodes were counted and matched to insertion site, then normalized to Time 0 controls and aggregated across replicates to calculate average per-gene fitness scores 21,33
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Of approximately 4,000 affected genes, 59% are upregulated while 41% are downregulated, generally shifting expression patterns from diseased toward healthier states