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By month 4, GI side effects fade into background noise for 85%+ of patients, leaving appetite suppression as the primary ongoing effect, which is the desired therapeutic response

Subsequent trials demonstrated cardiovascular benefits: in the SUSTAIN 6 trial, semaglutide reduced major adverse cardiovascular events by 26% in high-risk patients, a finding that led to FDA approval for cardiovascular risk reduction in January 2020

Use additional protection when starting or increasing GLP-1 doses If you just started taking a GLP-1 and are on birth control pills, you may want to add a second type of contraceptive to prevent pregnancy

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Sources like avocado, olive oil, fatty fish, and nuts provide essential fatty acids without adding excessive volume to meals

If you want to know how much of each vitamin and mineral you need from your total diet and how much is too much, see our chart at www.consumerlab.com/rdas/