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Interestingly rats given p53 inhibitors and amifostine did not have improved survival compared to controls, suggesting amifostine acts (at least in part) via a p53 dependent mechanism [55]
Importantly, this benefit was observed both in patients with and without PAP (positive airway pressure) therapy
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The upshot of all this is that citrulline may not be an "essential amino acid," but it acts like one
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