PubMed laboratory research record [PMID: 11945808] PubMed record related to this compound for laboratory literature review
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Obes Rev Off J Int Assoc Study Obes
While no single direct mechanism has been definitively established, fatigue likely results from multiple factors including substantial caloric restriction, gastrointestinal side effects, dehydration, and metabolic adaptation during weight loss
For example, the SELECT trial demonstrated that semaglutide reduced major cardiovascular events by 20% in overweight patients