Experimental evidence clearly demonstrates that GLP-1RAs such as liraglutide and semaglutide enhance AMPK activity, leading to increased expression of genes involved in mitochondrial fatty acid oxidation and diminished lipogenesis ( Concomitantly, GLP-1RAs suppress the expression of lipogenic transcription factors and enzymes, including sterol regulatory element-binding protein 1c (SREBP-1c) and fatty acid synthase (FAS), resulting in reduced de novo lipogenesis
Finally, our study is limited by the lack of publicly available GWAS summary statistics for etiology-stratified MASLD-related complications (e.g., Hepatitis B Virus (HBV)-negative or non-viral HCC)
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Anti-inflammatory Effects: Chronic inflammation plays a pivotal role in the development and progression of cardiovascular disease
Russo, C., Russo, A., Pellitteri, R