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However, dose-dependent gastrointestinal effects limit efficacy, so drugs with GLP-1 and GCG pharmacology can also target alternative pathways and may expand the therapeutic index (132)
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Starner RJ, McClelland L, Abdel-Malek Z, Fricke A, Scott G
The incidence of nausea and of vomiting was highest among participants who received orforglipron at a dose of 24 mg
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