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Ameliorative effect of rosiglitazone, a peroxisome proliferator gamma agonist on adriamycin-induced cardio toxicity via suppressing oxidative stress and apoptosis

Key genetic variants in the GLP1R gene (such as rs6923761), GIPR gene (rs1800437), FTO (rs9939609), and MC4R (rs17782313) regulate appetite signaling, energy expenditure, and fat storage capacity

Figure 1: Folate metabolism starts with polyglutamate folates (a form of Vitamin B9), which are broken down by the enzyme dihydrofolate reductase (DHFR) into dihydrofolate and then tetrahydrofolate (THF)

Together, they address healing from two complementary angles

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