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If too many free radicals build up, they create oxidative stress, which harms cells and speeds up aging

Weight regain is well documented: the STEP 4 trial found that people who stopped after 20 weeks regained an average of 6.8% of their body weight over the following months

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These are not substitutes for titration adjustment, but they increase the chance that a given dose becomes tolerable

The target muscle, vastus lateralis, is halfway between your groin and your knee, about 6 8 inches from the crease of your leg