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35 VergunstCEGerlagDMLopatinskayaLKlareskogLSmithMDvan den BoschFet al
186,187,509,510 The accumulated DNA oxidative damage in AD hyper-activates the DNA damage sensor PARP-1, thereby reducing the concentration of cellular NAD + and suppressing the function of NAD + -SIRT1-PGC-1 axis, which in turn causes abnormal mitochondria
CT2 is also involved in the intracellular accumulation of bleomycin in human testicular cancer cells, which are sensitive to this drug (Table 1)
PMCID: PMC10385428
doi:10.1186/s12970-020-00377-2
Morrow CS, Smitherman PK, Diah SK, Schneider E, Townsend AJ
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