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doi: 10.1136/gutjnl-2018-316723 11 CaniP

Adding significant GLP-1-driven muscle loss on top of natural age-related decline can accelerate a process that was already working against you

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While there is no absolute contraindication, alcohol can: Increase nausea and gastrointestinal distress Contribute empty calories that undermine weight management efforts Potentially increase the risk of hypoglycemia in patients also taking diabetes medications Impair judgment regarding portion control and food choices Potentially increase pancreatitis risk, especially with heavy consumption Patients should discuss alcohol use with their healthcare provider and, if consuming alcohol, do so in moderation (defined as up to one drink per day for women and up to two drinks per day for men)

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Oral delivery of peptides and proteins: pharmacokinetic boundaries, negative selection, and route triage