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In men, lean body mass was significantly increased by 1.26 kg along with notable improvements in wellbeing and libido [5]

The normal LH group did not show a response at either timepoint, suggesting a different neurochemical cause for their hypothalamic amenorrhea

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At the same time, the pleiotropic, neurotrophic and neuroprotective properties of GLP-1RAs are also obvious and, taking into account the ability to enhance the energy metabolism of neurons and optimize synaptic plasticity these beneficial effects position GLP-1RAs as potential agents modifying brain diseases [109, 110]

Conclusions The study findings highlight the role of BDNF-TrkB signaling in cellular metabolism and dopamine regulation

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