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The therapeutic application of GLP-1 agonists for obesity is grounded in well-established physiological mechanisms that extend beyond glucose regulation to encompass appetite control and energy homeostasis

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Pregnancy Animal studies suggest that Rybelsus could be harmful to the fetus, so it may not be safe to use during pregnancy

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Retatrutide won't be available until at least early 2026 as it's still in phase-3 clinical trials