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Considering dopamines pivotal role in the brains reward system, such alterations could lead to an imbalance in dopaminergic neurotransmission 43,44

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Other recognised contributors to RLS include chronic kidney disease (particularly uraemia), pregnancy, and certain medications such as some antidepressants (SSRIs/SNRIs), antipsychotics, and dopamine antagonists (including anti-nausea medications like metoclopramide)