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A 2023 World Health Organization (WHO) systematic review and guideline on non-sugar sweeteners cautioned against their long-term use for weight control, noting limitations in the evidence base

121123 Consequently, drug-metabolizing enzyme-mediated DDIs, typically involving competition for the same CYP binding site with another drug, are uncommon in peptide drug-related DDIs

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Compounded retatrutide from a licensed pharmacy is manufactured under regulatory oversight, but it has not undergone FDA review for safety and efficacy