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Notably, the acetylation of histones plays a role in the regulation of gene expression by facilitating transcription (i.e., mRNA synthesis), while deacetylated histones are usually associated with chromatin compaction and gene silencing

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Ageing is a natural driver of this decline, but environmental toxins, poor nutrition, and chronic stress also play a significant role

Pickart was studying liver tissue regeneration and noticed that a small peptide fraction isolated from human plasma significantly accelerated repair in older liver cells, restoring their behavior to something closer to younger cells

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