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Early diagnosis of this syndrome and implementing a multidimensional therapeutic approach is paramount for a successful outcome

Reproduction in another laboratory makes the conclusion robust

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By transiently expressing full-length SsVSPs FL or signal peptide (SP)-removed SsVSPs SP in Nicotiana benthamiana , we found that SsVSP31 SP promoted S

This finding agrees with the literature whereby the role of quinone redox metabolism is an ambiguous source of toxicity, with evidence suggesting that redox cycling requires supra-pharmacological concentrations of doxorubicin to generate substantial ROS in tissues and cells 10

But a gap in data is not evidence of harm, and every mechanistic signal we have points the other way