However, megadosing (taking excessive amounts of vitamin B12) may lead to some negative side effects
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A significant portion is excreted within the first 8 hours
Craig M, Temples HS, Weir B
However, these pathological manifestations were not exclusive of the modulations of epithelial homeostasis: NCAD delta expression perturbed proliferation, migration, and death programs in crypts, also leading to adenoma production
Persistently high levels warrant medical investigation to identify any underlying cause