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Oral vitamin C is absorbed in the small intestine and transported to tissues until saturated

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In line, lactate also accumulated to a higher extent in the culture medium of Gclc fl/fl Mb1-Cre + FoB as compared to control cells (Fig

This result warrants caution: oral bioavailability of hexapeptides is generally very low due to gastrointestinal degradation and poor intestinal absorption, and the finding has not been widely replicated or supported by pharmacokinetic data confirming systemic absorption at meaningful levels

[1] It is a ubiquitous compound with a biologically active sulfhydryl group contributed by the cysteine moiety that acts as the active part of the molecule