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Stress management at the ER: Regulators of ER stress-induced apoptosis
Often chosen, this approach is speedier and more easily observable
Further development of TGR-based therapeutic approaches is impeded by the lack of non-covalent small molecule inhibitors of TGR, a well-known and general problem for all the members of the high molecular weight, Sec-containing TrxR subfamily that are considered attractive and unexploited drug targets for several human diseases 21,22
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