The primary outcome was a composite of the first occurrence of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke
GIP receptor activation appears to enhance insulin release in a glucose-dependent manner, complementing GLP-1s effects and potentially reducing the risk of hypoglycemia in certain models
Curr Pharm Des (2005) 11(32):414551
JAMA pediatrics , 173 (4), 319325
At the same time, glucagon signalling can affect blood glucose, which is one reason retatrutides combined receptor profile requires careful clinical evaluation
Similarly, the authors reported a significant improvement in liver fibrosis without MASH aggravation