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Theranostics 7 , 47354752 (2017)

I believe the rush toward higher doses reflects a common misconception that more equals better

Importantly, bi-functionalization significantly enhances BBB permeability in vitro and in vivo by up to five-fold compared to mono-functionalized liposomes because of the optimized size ( 2x) and 46% release at pH 5.5, facilitating cytosolic delivery, while being stable at pH 7.4

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