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Studies show that approximately two-thirds of the weight lost on GLP-1 therapy is regained within one year of discontinuation if no other interventions are in place

Aside from semaglutide and tirzepatide, other notable GLP-1 agonists are dulaglutide, liraglutide, and exenatide

published in Diabetes, Obesity and Metabolism examined data from 52 randomized controlled trials involving over 75,000 participants treated with GLP-1 receptor agonists

Comparative safety of pharmacologic treatments for persistent depressive disorder: a systematic review and network meta-analysis