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Maintenance of Lost Weight and Long-Term Management of Obesity

Improvement in insulin sensitivity The recent finding that GIP/GLP-1 receptor co-agonists like tirzepatide have superior efficacy compared to selective GLP-1 receptor agonists with respect to glycemic control as well as body weight has renewed interest in GIP [20], which previously was thought to be without any therapeutic potential

Beginners often use them in combination under medical supervision, but dosage timing should always be individualized and physician-guided

To this end, we performed a dose-finding study in PWA mice, as model with more severe metabolic alterations, testing the doses of 5, 10, and 25 nmol/kg of GLP1/E

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