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The issue is usually temporary and not severe enough to become problematic

One product leaflet for B12 states 50-98% of injected B12 is excreted with the urine

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Storage After Reconstitution Do This Store in refrigerator at 36-46F (2-8C) Keep away from light (store in box if possible) Use within 28-60 days of reconstitution Inspect for particles before each use Always swab the stopper before drawing Never Do This Never freeze reconstituted retatrutide Don't leave at room temperature for extended periods Don't use if solution is cloudy or has particles Don't use past the expiration date Never share vials or needles Stability note: While some sources cite 60-day stability, 28 days is the more conservative recommendation for compounded peptides