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But the logic is sound

After activating GLP-1R, Semaglutide TFA promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis

The active pharmaceutical ingredient, semaglutide, is the same molecule in both

doi: 10.1378/chest.117.1.163 88 HirschJChalkleyRJBentleyTBurlingameALFrankJA

Amputation of the toe and mid-foot were most frequent (21 out of 28 JARDIANCE 10 mg treated patients with lower limb amputations), and some involving above and below the knee

Individual results depend on factors including starting weight, dose, lifestyle changes, and adherence to treatment