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Why GLP-1 Medications Affect the Digestive System The connection between GLP-1 medications and digestive symptoms stems directly from how these drugs alter normal gut function
In both peptides, the N-terminal histidine sits in an enclosed pocket-forming hydrophobic and hydrogen bond interactions with E364 6.53 , E387 7.42 , R310 5.40 , Y241 3.44 , W306 5.36 , I313 5.43 and Q234 3.37 however, these interactions are more persistent with GLP-1, and this is likely linked to the stability of interactions of Glu9 and with residues at the base of the binding cavity (Supplementary Table 3, Supplementary Movie 1)
The gut microbiota converts L-carnitine into trimethylamine (TMA), which may then be oxidized by enzymes in the liver to form trimethylamine N-oxide (TMAO)
Lean muscle mass loss occurs proportionally with weight loss, highlighting the importance of resistance exercise and adequate protein intake to preserve muscle and bone health
Acknowledgements The authors declare financial support was received for the research, authorship, and/or publication of this article
Chemico-Biological Interactions, 70
