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Presynaptic GLP-1 receptors enhance the depolarization-evoked release of glutamate and GABA in the mouse cortex and hippocampus

These pathways are well-characterized in rodent models, though further confirmation in humans is needed

GLP-1 analogs demonstrated efficacy in cases refractory to other treatment modalities, often in cases of patients with obesity who would experience additional benefits from starting therapy

A receptor first understood as a pancreatic switch for insulin turned out to sit across circuits that govern reward, memory, mood, and movement, and the drugs that engage it have become some of the most-studied molecules in medicine

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