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Berjis rule of thumb makes the distinction even easier to understand: Maintenance is like wearing comfy sneakers every day, while microdosing is like only wearing them when you know youll be walking a lot. It all comes down to timing and individual needs.
FDA approval in the US is expected in 2026 to 2027, with Health Canada approval likely following
Stomach and Digestive Side Effects Digestive problems are the most common issues experienced by patients taking GLP-1 injections
For those planning pregnancy, specific washout periods apply (e.g., discontinue semaglutide at least 2 months before planned conception)
The quality of available evidence is further limited by methodological concerns, including small sample sizes, short study durations, lack of standardisation in probiotic formulations, and potential publication bias favouring positive results
Annu Rev Biochem 1988
